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Crossbow Therapeutics is looking for a

Senior Research Associate / Associate Scientist, Protein Production and Purification

Crossbow Therapeutics, Inc., is a biotechnology company determined to improve the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. The company’s T-BoltTM therapies are next-generation, easily assembled immunotherapies directed with high precision at previously unreachable cancer cell targets. Crossbow’s efficient and selective approach is designed to target the entire universe of cancer proteins, dramatically expanding the potential of antibody therapy to address many types of cancer. 

Join us on our bold quest to broaden the benefits of immunotherapy and improve the lives of people living with cancer. For more information, visit us at

About The Opportunity 

This is a full-time position with an opportunity to be a part of a scientific lab team. The job title will be based on the individual’s prior experience.

Key Responsibilities: 

  • Mammalian cell culture skill. 

  • Express recombinant proteins and antibodies from mammalian culture. 

  • Perform high-throughput routine antibody purification using AKTA system with analytical techniques. 

  • Characterize recombinant antibodies/proteins using SDS-PAGE, protein quantitation, HPLC, ELISA and other biochemical assays to determine protein purity and function.

  • Molecular biology techniques; PCR, Plasmid DNA preparation, bacterial transformation.

  • Mammalian cell culture assays (T cell killing/activation/cytokine release).

  • Analyze and interpret data and prepare reports and presentations for internal and external stakeholders. 

  • Maintain accurate records of experiments and data analysis. 

  • Collaborate with cross-functional teams to ensure timely completion of project milestones. 

  • Stay up to date with the latest scientific and technological advancements in the field of antibody purification.

Preferred qualifications and past experience: 

  • Experience with recombinant antibody and protein expression and purification using mammalian cell lines is desirable.

  • Experience with FPLC systems and with affinity, IEX and SEC protein purification methods is desirable.

  • Experience with general in vitro cell culture/immunology techniques and culture of primary cell lines a plus.

  • Bachelor's or Master's degree in Biochemistry, Chemistry, or a related field with a minimum of 3 years of protein purification experience. 

  • Experience in analytical methods for assessing the quality and purity of antibodies, such as SDS-PAGE and analytical SEC using HPLC system. 

  • Cell culture techniques 

  • Excellent communication, organizational, and project management skills.


To apply for this role: Send your resume directly to

Location: This position is on site Monday-Friday.  Crossbow Therapeutics is located at 1030 Massachusetts Ave. Suite 210, Cambridge, Massachusetts. 

To all agencies: All resumes submitted by search firms/employment agencies at Crossbow via email, the internet, or in any form and/or method will be deemed the sole property of Crossbow Therapeutics and no fee will be paid by Crossbow, unless such search firms/employment agencies were engaged by Crossbow for this position and a valid agreement is in place.

A note about recruitment scams: Please be aware of potential recruitment scams, which can appear like legitimate work opportunities where the scammer pretends to work at Crossbow Therapeutics. To help protect yourself from those types of scams, please know that

  • Crossbow will never ask for money or fees at any point during the interview process - if you are being asked to send money as part of your interaction, do not send money;

  • Crossbow never asks applicants to communicate through Telegram or Skype - if you are being asked to download Telegram or Skype for a job interview, do not download;

  • Crossbow employees will only email you from an official email account.

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