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Crossbow Therapeutics is looking for a

Senior/ Principal Scientist, Biology

Crossbow Therapeutics, Inc., is a biotechnology company determined to improve the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. The company’s T-BoltTM therapies are next-generation, easily assembled immunotherapies directed with high precision at previously unreachable cancer cell targets. Crossbow’s efficient and selective approach is designed to target the entire universe of cancer proteins, dramatically expanding the potential of antibody therapy to address many types of cancer. 

Join us on our bold quest to broaden the benefits of immunotherapy and improve the lives of people living with cancer. For more information, visit us at

About The Opportunity 

Reporting to the Associate Director, Biology, this is an exciting opportunity to be part of an early-stage company and contribute to next-generation immunotherapies. 

Key Responsibilities: 

  • Lead the design and execution of immune cell-based experiments, using both primary cells and cell lines.

  • Independently work to generate, critically analyze and interpret data with scientific rigor and an open mind.

  • Work collaboratively with scientists and research associates within and across teams to accomplish program goals.

  • Perform T cell dependent cellular cytotoxicity assays.

  • Multiparameter flow cytometry-based analysis of cell lines and primary T cells.

  • Thorough documentation of experiments and communication of results with scientific
    team members and stakeholders.

  • Contribute to maintaining a creative and safe laboratory environment.

Preferred qualifications and past experience: 

  • Ph.D. in Immunology or Cancer Biology with 3+ years of experience in either an academic or industrial setting. M.S. with 8+ years of experience in Immunology or Cancer Biology.

  • The ideal candidate would have strong background in Immunology with understanding how cytotoxic T cell recognize and eliminate target cells.

  • Extensive experience in cell culture, including primary lymphocyte cultures.

  • Demonstrated experience with flow cytometry, including FlowJo data analysis.

  • Experience with techniques related to T cell immunology and tumor immunotherapy,

  • such as ELISpot and ELISA.

  • Familiarity with T cell functional assays such as T cell dependent cellular cytotoxicity

  • assays using systems such as the Incucyte live cell imaging system.

  • Ability to work in an interdisciplinary scientific team and the desire to learn new

  • techniques.

  • Must be able to work independently as well as collaboratively in a fast-moving small

  • biotech environment.

  • Outstanding pro-active attitude, interpersonal, collaborative, communication skills, and

  • ability to present research to a variety of audiences.

  • A creative, flexible and self-motivated individual is highly desired.

  • The candidate must have a passion for conducting experiments and being part of a strong lab team.


To apply for this role: Send your resume directly to

Location: This position is on-site, Monday-Friday. Crossbow Therapeutics is located at 1030 Massachusetts Ave. Suite 210, Cambridge, Massachusetts.

To all agencies: All resumes submitted by search firms/employment agencies at Crossbow via email, the internet, or in any form and/or method will be deemed the sole property of Crossbow Therapeutics and no fee will be paid by Crossbow, unless such search firms/employment agencies were engaged by Crossbow for this position and a valid agreement is in place.

A note about recruitment scams: Please be aware of potential recruitment scams, which can appear like legitimate work opportunities where the scammer pretends to work at Crossbow Therapeutics. To help protect yourself from those types of scams, please know that

  • Crossbow will never ask for money or fees at any point during the interview process - if you are being asked to send money as part of your interaction, do not send money;

  • Crossbow never asks applicants to communicate through Telegram or Skype - if you are being asked to download Telegram or Skype for a job interview, do not download;

  • Crossbow employees will only email you from an official email account.

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