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Crossbow Therapeutics is looking for a full-time

Senior Research Associate/ Associate
Scientist in Protein Analytics

Crossbow Therapeutics, Inc., is a biotechnology company determined to improve the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. The company’s T-Bolt™ therapies are next-generation, easily assembled immunotherapies directed with high precision at previously unreachable cancer cell targets. Crossbow’s efficient and selective approach is designed to target the entire universe of cancer proteins, dramatically expanding the potential of antibody therapy to address many types of cancer.

Join us on our bold quest to broaden the benefits of immunotherapy and improve the lives of people living with cancer. For more information, visit us at

About The Opportunity 

The (Sr) Research Associate/Associate Scientist will join efforts of Antibody Discovery, Protein
Engineering and Process Development team to develop safe and effective T-cell engager therapies. The candidate will have an opportunity to contribute to groundbreaking research working with a team of enthusiastic scientists.

Key Responsibilities: 

  • Perform protein characterization using multiple biophysical and biochemical techniques (i.e. SEC, HIC, IEX, SDS-PAGE, BLI), as well as other assessment tools.

  • Perform stability assessment of proteins (antibodies and antigens)

  • Support the development, optimization, and troubleshooting of analytical methods for protein characterization.

  • Maintain and troubleshoot analytical equipment.

  • Perform protein purification from bacterial protein expression system and further protein analysis and characterization.

  • Maintain well-organized electronic notebook records of experimental data, author technical protocols and reports, communicate experimental results to the team.

  • Collaborate with other scientists to support the development of innovative testing technologies.

Preferred qualifications and past experience: 

  • Bachelor's or Master's degree in Biochemistry, Chemistry, or a related field with a minimum of 2 years of protein characterization experience.

  • Working technical expertise in analytical methodologies used to characterize protein therapeutics including SEC, IEX, HIC, CE-SDS, SDS-PAGE, etc.

  • Experience with characterization of protein-protein interactions (BLI, ELISA)

  • Experience in protein purification from bacterial protein expression system.

  • Experience handling, maintaining, and troubleshooting LC instruments (Agilent)

  • Experience with LC data analysis and interpretation.

  • Ability to work in a matrix team environment.

  • Excellent written and oral communication skills.

  • Experience using electronic notebooks (Benchling experience a plus!)


To apply for this role: Send your resume directly to

Location: This position is on site Monday-Friday.  Crossbow Therapeutics is located at 1030 Massachusetts Ave. Suite 210, Cambridge, Massachusetts.

To all agencies: All resumes submitted by search firms/employment agencies at Crossbow via email, the internet, or in any form and/or method will be deemed the sole property of Crossbow Therapeutics and no fee will be paid by Crossbow, unless such search firms/employment agencies were engaged by Crossbow for this position and a valid agreement is in place.

A note about recruitment scams: Please be aware of potential recruitment scams, which can appear like legitimate work opportunities where the scammer pretends to work at Crossbow Therapeutics. To help protect yourself from those types of scams, please know that

  • Crossbow will never ask for money or fees at any point during the interview process - if you are being asked to send money as part of your interaction, do not send money;

  • Crossbow never asks applicants to communicate through Telegram or Skype - if you are being asked to download Telegram or Skype for a job interview, do not download;

  • Crossbow employees will only email you from an official email account.

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